Package-Ref™ MRD Cocktail Reference Standard

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Package-RefTM MRD Cocktail Reference Standard
Cat No.	CBP90040
Descripition	MRD refers to the residual tumor cells or markers in the body after treatment. There are usually three translations: Minimal Residual Disease, Measurable Residual Disease, and Molecular Residual Disease.

Product Description
Catalog ID	Name	%AF	Specification	Concentration	Remark
CBP90040-1	Package-RefTM MRD Cocktail Reference Standard-0.5%	0.50%	500 ng/vial	20 ng/µL	Optimized ddPCR assay
CBP90040-2	Package-RefTM MRD Cocktail Reference Standard-0.05%	0.05%	500 ng/vial	20 ng/µL	Dilution fold-confirmation
CBP90040-3	Package-RefTM MRD Cocktail Reference Standard-0.005%	0.005%	500 ng/vial	20 ng/µL	Dilution fold-confirmation
CBP90040-4	Package-RefTM MRD Cocktail Reference Standard-0%	0.00%	500 ng/vial	20 ng/µL	ddPCR assay

MRD-0.5% ctDNA
GENE	Mut.	CDS change	Variant Classification	AF%
EGFR	p.E746_A750delELREA	c.2236_2250del15 GAATTAAGAGAAGCA>-	Pathogenic	0.69
EGFR	p.S768I	c.2303G>T	Pathogenic	0.61
EGFR	p.L861Q	c.2582T>A	Pathogenic	0.61
ERBB2	p.A775_G776insYVMA	c.2324_2325ins12 ATACGTGATGGC	Pathogenic	0.41
KRAS	p.G12V	c.35G>T	Pathogenic	0.39
PIK3CA	p.E542K	c.1624G>A	Pathogenic	0.62
KRAS	p.Q61H	c.183A>C	Pathogenic	0.49
EGFR	p.G719C	c.2155G>T	Pathogenic	0.5
ROS1	CD74-ROS1	chr5:149783684:- (hg19) chr6:117646732:- (hg19)	Pathogenic	0.55
NRAS	p.Q61K	c.181C>A	Pathogenic	0.41
IDH1	p.R132C	c.394C>T	Pathogenic	0.43
FBXW7	p.R505C	c.1513C>T	Pathogenic	0.75
KMT2C	p.F4496Lfs*21	c.13488delA	Likely Pathogenic	0.46
RAC1	p.N92I	c.275A>T	Pathogenic	0.4
BCOR	p.Q1321*	c.3961C>T	Likely Pathogenic	0.68
BRCA2	p.M784V	c.2350A>G	Benign	0.64
ARID1A	p.G1848Wfs*6	c.5540dupG	Likely Pathogenic	0.61
CDH1	p.P126Rfs*89	c.377delC	Pathogenic	0.74
BARD1	p.K208Rfs*4	c.623delT	Likely Pathogenic	0.38
BAX	p.E41Rfs*19	c.121delG	Pathogenic	0.75
NBN	p.R466Gfs*18	c.1396delT	Pathogenic	0.71
KMT2D	p.Q809Rfs*121	c.2425delG	Likely Pathogenic	0.51
KMT2D	p.P647Hfs*283	c.1940delG	Pathogenic	0.44
QKI	p.K134Rfs*14	c.401delA	Likely Pathogenic	0.63
KMT2B	p.W336*	c.1007G>A	Likely Pathogenic	0.75
NSD1	p.M1531Cfs*43	c.4591delA	Likely Pathogenic	0.74
AXIN1	p.E31*	c.91G>T	Likely Pathogenic	0.66
AXIN1	p.G508Vfs*197	c.91G>T	Likely Pathogenic	0.69
ARID1B	p.A547Sfs*35	c.1638_1647del GGGCGGCGGC	Pathogenic	0.47
HLA-C	p.V100Efs*38	c.299_300delTG	Likely Pathogenic	0.51
TP53BP1	p.R1447Efs*36	c.4339delC	Likely Pathogenic	0.57
POLD1	N/A	c.E24-2AG>A	Likely Pathogenic	0.73
CYLD	p.N722Mfs*13	c.2165delA	Likely Pathogenic	0.57
INHA	p.G66Afs*61	c.197delG	Likely Pathogenic	0.74
RASA1	p.N838Mfs*4	c.2513delA	Likely Pathogenic	0.51
RECQL4	p.G952Afs*92	c.2855delG	Likely Pathogenic	0.54
BRAF	p.V600E	c.1799T>A	Pathogenic	5.33
ACVR2A	p.K437Rfs*5	c.1310delA	Likely Pathogenic	3.98
PIK3CA	p.H1047R	c.3140A>G	Pathogenic	2.81
BRCA1	p.D435Y	c.1303G>T	Uncertain significance	2.53
BRCA2	p.N1784Tfs*7	c.5351delA	Pathogenic	2.35
BRCA2	p.E2292A	c.6875A>C	Uncertain significance	1.35
TP53	N/A	c.783-2A>C	Pathogenic	1.02
CDKN2A	p.R80*	c.238C>T	Pathogenic	0.92
HLA-A	p.R45Afs*32	c.133del	Likely Pathogenic	1.25

Dilution Validation Data
GENE	Mutation	AF% of MRD-0.5% ctDNA	AF% of MRD-0.05% ctDNA	AF% of MRD-0.005% ctDNA
BRAF	p.V600E	5.33	0.54	0.047
ACVR2A	p.K437Rfs*5	3.98	0.40	0.038
PIK3CA	p.H1047R	2.81	0.26	N/A
BRCA1	p.D435Y	2.53	0.24	N/A
BRCA2	p.N1784Tfs*7	2.35	0.23	N/A
BRCA2	p.E2292A	1.35	0.14	N/A
TP53	c.783-2A>C	1.02	0.11	N/A
CDKN2A	p.R80*	0.92	0.10	N/A
HLA-A	p.R45Afs*32	1.25	0.11	N/A

Product Information
Intended Use	Research Use Only
Unit Size	4 pieces/set, 0.5μg/piece, 20ng/μL
Storage	-20℃
Expiry	36 months from the date of manufacture

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